週次 |
日期 |
單元主題 |
第1週 |
9/16 |
Course Introduction: why I should/should not take this course? (為何我要修 (或不修) 這門課?)
|
第2週 |
9/23 |
Milestone 1 (1952) Electophoresis; Milestone 2 (1967, 1972) Discovery of DNA ligase; Cloning The dawn of recombinant DNA |
第3週 |
9/30 |
Milestone 3 (1969) FISH (fluorescent in situ hybridization); Milestone 4 (1970) Discovery of restriction enzymes |
第4週 |
10/07 |
Milestone 5 (1970, 1998) Discovery of reverse transcriptase; Full-length cDNA technologies; Milestone 6
(1975) Southern blot |
第5週 |
10/14 |
Milestone 7 (1977) DNA sequencing; Milestone 8 (1980, 1983) RFLP concept; RFLP realization |
第6週 |
10/21 |
Milestone 9
(1982, 1987) P-element-mediated manipulation of the fly genome; Site-directed mutagenesis of the mouse genome; Milestone 10 (1982) Whole genome shotgun |
第7週 |
10/28 |
Milestone 11 (1985) PCR; Milestone 12 (1985) DNA Fingerprinting |
第8週 |
11/04 |
期中考與期中座談 (或參觀見學) |
第9週 |
11/11 |
Milestone 13 (1987, 1992) YACs and BACs; Milestone 14
(1988) ChIP |
第10週 |
11/18 |
Milestone 15 (1990) BLAST — the key to comparative genomics; Milestone 16 (1995) Microarray technology |
第11週 |
11/25 |
Milestone 17 (1998) RNAi |
第12週 |
12/02 |
Milestone 18 (1998, 2005) Sequencing by synthesis; Sequencing by ligation/polony sequencing; Milestone 19 (2002) Launch of UCSC Genome Browser |
第13週 |
12/09 |
Milestone 20 (2003) DNA assembly programs; Milestone 21
(2004) ENSEMBL — an example of a gene annotation tool |
第14週 |
12/16 |
Milestone 22 (2005) HapMap; Milestone 23 (2006) Genome-wide maps of DNA methylation |
第15週 |
12/23 |
DNA 科技研究趨勢座談 |
第16週 |
12/30 |
DNA 科技研究經驗座談 |
第17週 |
1/06 |
期末考與期末座談 |